Definition of immune staining of the entire retina of the retina

What is the function of the cone-rich rim of the retina?

Abstract

Although there is good histological evidence for a rim of cones extending round the margin of the human retina at the ora serrata, the function of these cones is unknown, and indeed it is not known whether they are functional at all. Four possibilities are discussed here : (i) the cones of the ora serrata may alert us to sudden movements in the far peripheral field, (ii) their signal may be used in estimating optic flow during locomotion, (iii) they may integrate light scattered within the globe of the eye or passing through the sclera, for purposes of color constancy, or (iv) they may drive circadian rhythms. We report two experiments designed to detect psychophysical correlates of the cone rim. Under the conditions we have used, neither flicker detection nor color naming show, near the limit of vision, a discontinuity that would correspond to the cone-rich rim.

References

  1. 1

    Polyak SL. The retina. Chicago: University of Chicago Press, 1941.

  2. 2

    Schultze M. On the anatomy and physiology of the retina. Arch Mikrosc Anat 1866;2:174–286.

    Google Scholar

  3. 3

    Greeff R. Microscopic anatomy of the optic nerves and retina. In: von Graefe A, Saemisch T, editors. Handbook of all ophthalmology. Berlin: Springer, 1900.

  4. 4

    Williams RW. The human retina has a cone-enriched rim. Vis Neurosci 1991;6:403–6.

    CASArticle Google Scholar

  5. 5

    Hartridge H. The limit to peripheral vision. J Physiol (Lond) 1919;53:17.

    Article Google Scholar

  6. 6

    Druault A. Note on the situation des images rétiǹiènnes formées par les rayons très obliques sur l'axe optique. Arch d'Ophtalmol 1898;20:685–92.

    Google Scholar

  7. 7

    Jay BS. Pupil area at different eccentricities. Vision Res 1961;1:418–24.

    Article Google Scholar

  8. 8

    Donders FC. The limits of the field of vision in relation to those of the retina. Graefes Arch Ophthalmol 1877;2:255–80.

    Article Google Scholar

  9. 9

    Duke-Elder WS. Textbook of ophthalmology, vol I.. London: Kimpton, 1932.

  10. 10

    Thiel H-L. On the topographical and histological situation of the ora serrata. Graefes Arch Ophthalmol 1955;156:590–629.

    CASArticle Google Scholar

  11. 11

    Salzmann M. The anatomy and histology of the human eyeball in the normal state. Chicago: University of Chicago Press, 1912.

  12. 12

    Curcio CA, Sloan KR, Kalina RE, Hendrickson AE. Human photoreceptor topography. J Comp Neurol 1990;292:497–523.

    CASArticle Google Scholar

  13. 13

    Joussen F, Spitznas M. The fine structure of the human retina at the ora serrata. Graefes Arch Ophthalmol 1972;185:177–88.

    CASArticle Google Scholar

  14. 14

    Fine BS, Yanoff M. Ocular histology. New York: Harper & Row, 1972.

  15. 15

    Diaz-Araya CM, Provis JM, Billson FA. NADPH-diaphorase histochemistry reveals cone distributions in adult human retina. Aust NZ J Ophthalmol 1993;2:171–9.

    Google Scholar

  16. 16

    Parsons JH. An introduction to the theory of perception. Cambridge: Cambridge University Press, 1927.

  17. 17

    Schnapf J, Nunn BJ, Master M, Baylor DA. Visual transduction in cones of the monkey Macaca fascicularis. J Physiol (Lond) 1990;427:681–713.

    CASArticle Google Scholar

  18. 18

    Miller JL, Picones AP, Korenbrot JI. Differences in transduction between rod and cone photoreceptors: an exploration of the role of calcium homeostasis. Curr Opin Neurobiol 1994;4:488–95.

    CASArticle Google Scholar

  19. 19

    Helmholtz H. Manual of Physiological Optics. 1 ed.Leipzig: Leopold Voss, 1867.

  20. 20

    Gibson JJ. The perception of the visual world. Boston: Houghton Mifflin, 1950.

  21. 21

    Hellpach W. The color perception in indirect vision. Philosophical Studies 1900;15:524–54.

    Google Scholar

  22. 22

    Baird JW. The color sensitivity of the peripheral retina. Washington: Carnegie Institute, 1905.

  23. 23

    Baird JW. Review of: The color perception of the retinal periphery with dark adaptation and constant subjective brightness, by Wilhelm Peters. J Philos Psychol Sci Methods 1905;2:20–2.

    Google Scholar

  24. 24

    Pikler J. The eye cover light as a measure of colors. Z Psychol 1931;120:189–208.

    Google Scholar

  25. 25

    Arend L, Reeves A. Simultaneous color constancy. J Opt Soc Am A 1986;3:1743–51.

    CASArticle Google Scholar

  26. 26

    Munz FW, McFarland WF. Evolutionary adaptation of fishes to the photic environment. In: Crescitelli F, editor. Handbook of sensory physiology. Berlin: Springer, 1977.

  27. 27

    Mollon JD, Jordan G. An evolutionary interpretation of human color vision. The color 1988;35/36:139–70.

    Google Scholar

  28. 28

    Stiles WS. The directional sensitivity of the retina and the spectral sensitivities of the rods and cones. Proc R Soc Lond B 1939;127:64–105.

    Article Google Scholar

  29. 29

    O'Connell DJK. The green flash. Sci Am 1960;202:112.

    Article Google Scholar

Download references

Author information

Affiliations

  1. Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK

    J D Mollon & B C Regan

  2. Department of Visual Science, Institute of Ophthalmology, University College London, Bath Street, London, EC1V 9EL, UK

    J K Bowmaker

Corresponding author

Correspondence to J D Mollon.

additional information

This paper is dedicated to the memory of Professor H.J.A. Dartnall (1913-1998)

Supported by MRC grant 9712483

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Cite this article

Mollon, J., Regan, B. & Bowmaker, J. What is the function of the cone-rich rim of the retina ?. Eye12, 548-552 (1998). https://doi.org/10.1038/eye.1998.144

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Keywords

  • Color constancy
  • Cone
  • Cone streak
  • Flicker
  • Optic flow
  • Ora serrata
  • Peripheral retina

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