What does Maxin and Relaxin mean


1 definition

Relaxin is a peptide hormone that is produced in different places in women and men and that performs different functions.

2 biochemistry

Relaxin is a heterodimer consisting of two peptide chains with 24 and 29 amino acids, which are linked by disulfide bridges. There is a structural similarity to insulin. Three relaxins are known in humans:

  • Relaxin-1 (RLN1)
  • Relaxin-2 (RLN2)
  • Relaxin-3 (RLN3)

Four different relaxin receptors can be assigned to them - these are G-protein-coupled receptors.

3 function

In pregnant women, relaxin is formed in the uterus, placenta and mammary glands, but especially in the corpus luteum. At the end of pregnancy, it causes a remodeling of the extracellular matrix of the cervical canal and a strong loosening and stretching of the cervix ("mature cervix"). In addition, the symphysis of the female pelvis is relaxed, which makes the birthing process easier. In addition to these mechanisms, it is assumed that relaxin together with progesterone "keeps the uterus still" until the last month of pregnancy, ie prevents premature uterine contractions.

In men, relaxin is synthesized in the prostate and appears to have a positive effect on sperm motility and fertilization.