How are radiopharmaceuticals produced by cyclotrons


A Radiopharmaceutical (also Radiopharmaceutical) is a drug used in nuclear medicine. It can consist of a radioactive substance alone or of a carrier to which the radioactive substance is coupled. Radiopharmaceuticals are used in particular for diagnostics (radiodiagnostics) in scintigraphy, positron emission tomography (PET) and single photon emission computed tomography (SPECT), the difference being that there are no stationary methods compared to other methods such as x-rays States are mapped, but metabolic processes. In addition, radiopharmaceuticals can be used to treat illnesses or physical conditions (radiotherapeutic agents).

Radiopharmacy deals with the development and manufacture of radiopharmaceuticals.


Both its pharmacological properties (pharmacodynamics, pharmacokinetics) and the radiochemical properties of the nuclide (type of radiation, activity, half-life) determine the use of a radiopharmaceutical. Radionuclides that primarily emit beta radiation are primarily used for therapy, as they only emit intense radiation over short distances and their radioactive effect therefore remains in the body. Positron emitters (beta emitters) in PET are an exception. When they decay, they produce annihilation radiation (two coincident gamma quanta with 511 keV), which are registered by the PET scanner. Gamma emitters, on the other hand, whose rays extend over a longer distance but are less intense, are mainly used for diagnostics and are recorded by means of a gamma camera. Gamma emitters are also used as radiation sources in radiation therapy (e.g. for afterloading).

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